Andrew E Jaffe †

Latest

• Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
• Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex
• Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
• Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation
• Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia
• Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease