Joel E Kleinman

Latest

• Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood
• Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus
• Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
• Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex
• Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
• Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
• Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia
• Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease