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Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain
Maternal smoking during pregnancy (MSDP) is associated with significant cognitive and behavioral effects on offspring. While …
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Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain
Network nature of ligand-receptor interactions underlies disease comorbidity in the brain
Neurodegenerative disorders have overlapping symptoms and have high comorbidity rates, but this is not reflected in overlaps of risk …
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Network nature of ligand-receptor interactions underlies disease comorbidity in the brain
lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
Relative cell type fraction estimates in bulk RNA-sequencing data are important to control for cell composition differences across …
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lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
Transcriptomic analysis of the human habenula in schizophrenia
Pathophysiology of many neuropsychiatric disorders, including schizophrenia (SCZD), is linked to habenula (Hb) function. While …
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Transcriptomic analysis of the human habenula in schizophrenia
Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex
Background Cellular deconvolution of bulk RNA-sequencing (RNA-seq) data using single cell or nuclei RNA-seq (sc/snRNA-seq) reference …
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Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex
Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation
The dentate gyrus of the hippocampus is important for many cognitive functions, including learning, memory, and mood. Here, we …
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Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation
Comparison of gene expression in living and postmortem human brain
Molecular mechanisms of neuropsychiatric disorders are challenging to study in human brain. For decades, the preferred model has been …
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Comparison of gene expression in living and postmortem human brain
Detection of pathogenic splicing events from RNA-sequencing data using dasper
Although next-generation sequencing technologies have accelerated the discovery of novel gene-to-disease associations, many patients …
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Detection of pathogenic splicing events from RNA-sequencing data using dasper
recount-brain: a curated repository of human brain RNA-seq datasets metadata
The usability of publicly-available gene expression data is often limited by the availability of high-quality, standardized biological …
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recount-brain: a curated repository of human brain RNA-seq datasets metadata
RNA-seq transcript quantification from reduced-representation data in recount2
More than 70,000 short-read RNA-sequencing samples are publicly available through the recount2 project, a curated database of summary …
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RNA-seq transcript quantification from reduced-representation data in recount2