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APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex
The entorhinal cortex (ERC) is implicated in early progression of Alzheimer’s disease (AD). Here we investigated the impact of …
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APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex
Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, …
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Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
A molecular map of the living human brain from quantitative MRI
Profiling dynamic molecular processes in neurodegeneration in vivo remains a major clinical challenge. Limited brain tissue …
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A molecular map of the living human brain from quantitative MRI
Network nature of ligand-receptor interactions underlies disease comorbidity in the brain
Neurodegenerative disorders have overlapping symptoms and have high comorbidity rates, but this is not reflected in overlaps of risk …
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Network nature of ligand-receptor interactions underlies disease comorbidity in the brain
Comparison of gene expression in living and postmortem human brain
Molecular mechanisms of neuropsychiatric disorders are challenging to study in human brain. For decades, the preferred model has been …
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Comparison of gene expression in living and postmortem human brain
Detection of pathogenic splicing events from RNA-sequencing data using dasper
Although next-generation sequencing technologies have accelerated the discovery of novel gene-to-disease associations, many patients …
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Detection of pathogenic splicing events from RNA-sequencing data using dasper
recount-brain: a curated repository of human brain RNA-seq datasets metadata
The usability of publicly-available gene expression data is often limited by the availability of high-quality, standardized biological …
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recount-brain: a curated repository of human brain RNA-seq datasets metadata
RNA-seq transcript quantification from reduced-representation data in recount2
More than 70,000 short-read RNA-sequencing samples are publicly available through the recount2 project, a curated database of summary …
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RNA-seq transcript quantification from reduced-representation data in recount2