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Splicing accuracy varies across human introns, tissues, age and disease
Alternative splicing impacts most multi-exonic human genes. Inaccuracies during this process may have an important role in ageing and …
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Splicing accuracy varies across human introns, tissues, age and disease
Integrating gene expression and imaging data across Visium capture areas with visiumStitched
Background Visium is a widely-used spatially-resolved transcriptomics assay available from 10x Genomics. Standard Visium capture areas …
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Integrating gene expression and imaging data across Visium capture areas with visiumStitched
A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, …
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A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study of posttraumatic stress …
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Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood
Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.
Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been …
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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.
Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus
Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features, including differential symptomatology, drug …
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Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus
The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing …
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The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
TrkB-dependent regulation of molecular signaling across septal cell types
The lateral septum (LS), a GABAergic structure located in the basal forebrain, is implicated in social behavior, learning, and memory. …
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TrkB-dependent regulation of molecular signaling across septal cell types
Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets
Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human tissue is important for understanding disease …
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Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets
escheR: Unified multi-dimensional visualizations with Gestalt principles
The creation of effective visualizations is a fundamental component of data analysis. In biomedical research, new challenges are …
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escheR: Unified multi-dimensional visualizations with Gestalt principles