BrainSeq

Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.
Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been …
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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.
Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus
Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features, including differential symptomatology, drug …
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Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus
Transcriptomic analysis of the human habenula in schizophrenia
Pathophysiology of many neuropsychiatric disorders, including schizophrenia (SCZD), is linked to habenula (Hb) function. While …
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Transcriptomic analysis of the human habenula in schizophrenia
Navigating human brain gene expression measurements at different resolutions to study psychiatric disorders
Invited seminar by Mina Ryten
Last updated on Tue, Jun 20, 2023
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Navigating human brain gene expression measurements at different resolutions to study psychiatric disorders
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
Most studies of gene expression in the brains of individuals with schizophrenia have focused on cortical regions, but subcortical …
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Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review
Following the recent review by Merikangas et al. summarizing differential gene expression in schizophrenia, we wanted to provide …
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Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review
SPEAQeasy: a scalable pipeline for expression analysis and quantification for R/Bioconductor-powered RNA-seq analyses
Background. RNA sequencing (RNA-seq) is a common and widespread biological assay, and an increasing amount of data is generated with …
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SPEAQeasy: a scalable pipeline for expression analysis and quantification for R/Bioconductor-powered RNA-seq analyses
Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity
Background. Recent breakthroughs in psychiatric genetics have implicated biological pathways onto which genetic risk for psychiatric …
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Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity
SynGAP isoforms differentially regulate synaptic plasticity and dendritic development
SynGAP is a synaptic Ras GTPase-activating protein (GAP) with four C-terminal splice variants: α1, α2, β, and γ. Although studies have …
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SynGAP isoforms differentially regulate synaptic plasticity and dendritic development
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
Jaffe et al. profile the granule cell layer of the human hippocampus and find unique molecular associations for aging and genetic variation, as well as diagnosis with schizophrenia and its genetic risk, that were previously undiscovered in homogenate tissue.
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Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk