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Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala
Fentanyl is a potent synthetic opioid associated with overdose. However, little is known about fentanyl-induced molecular adaptations …
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Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala
BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus
Divergent transcription from bidirectional promoters is frequently observed in eukaryotic genomes, but the biological relevance of …
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BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
The human brain’s dorsal anterior cingulate cortex (dACC) is critical in cognitive control, specifically reward processing and conflict …
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An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
Transcriptomic analysis of the human habenula in schizophrenia
Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic …
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Transcriptomic analysis of the human habenula in schizophrenia
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
Cell types in the hippocampus with unique morphology, physiology and connectivity serve specialized functions associated with cognition …
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An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
Background: Relative cell type fraction estimates in bulk RNA-sequencing data are important to control for cell composition differences …
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lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons
Major Depressive Disorder (MDD) is a common, complex disorder that is a leading cause of disability worldwide and a significant risk …
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Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons
Benchmark of cellular deconvolution methods using a multi-assay dataset from postmortem human prefrontal cortex
Cellular deconvolution of bulk RNA-sequencing data using single cell/nuclei RNA-seq reference data is an important strategy for …
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Benchmark of cellular deconvolution methods using a multi-assay dataset from postmortem human prefrontal cortex
Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation
The dentate gyrus of the hippocampus is important for many cognitive functions, including learning, memory, and mood. Here, we present …
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Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation
Splicing accuracy varies across human introns, tissues, age and disease
Alternative splicing impacts most multi-exonic human genes. Inaccuracies during this process may have an important role in ageing and …
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Splicing accuracy varies across human introns, tissues, age and disease