2

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
Cell types in the hippocampus with unique morphology, physiology and connectivity serve specialized functions associated with cognition …
Cite Project DOI Preprint Code Bioconductor
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
Background: Relative cell type fraction estimates in bulk RNA-sequencing data are important to control for cell composition differences …
Cite Project DOI Preprint Code Bioconductor
lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons
Major Depressive Disorder (MDD) is a common, complex disorder that is a leading cause of disability worldwide and a significant risk …
Cite Project DOI Code
Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons
Benchmark of cellular deconvolution methods using a multi-assay dataset from postmortem human prefrontal cortex
Cellular deconvolution of bulk RNA-sequencing data using single cell/nuclei RNA-seq reference data is an important strategy for …
Cite Project DOI Preprint Code Bioconductor
Benchmark of cellular deconvolution methods using a multi-assay dataset from postmortem human prefrontal cortex
Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation
The dentate gyrus of the hippocampus is important for many cognitive functions, including learning, memory, and mood. Here, we present …
Cite Project DOI Preprint Code
Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation
Splicing accuracy varies across human introns, tissues, age and disease
Alternative splicing impacts most multi-exonic human genes. Inaccuracies during this process may have an important role in ageing and …
Cite Project DOI Preprint Code
Splicing accuracy varies across human introns, tissues, age and disease
Integrating gene expression and imaging data across Visium capture areas with visiumStitched
Background Visium is a widely-used spatially-resolved transcriptomics assay available from 10x Genomics. Standard Visium capture areas …
Cite Project DOI Preprint Code Bioconductor
Integrating gene expression and imaging data across Visium capture areas with visiumStitched
A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, …
Cite Project DOI Preprint Code snRNA-seq code Documentation
A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study of posttraumatic stress …
Cite DOI Code
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood
Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.
Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been …
Cite Project DOI Preprint Code
Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.